LOTTO appears for the first time in Italy during the 18th century, under the name "Lotto di Genova" with an initial number combination "5 from 90".
On December 25, 1990 it is launched in Greece. The initial column price is 30 drachmas and since 26/10/1994 it changes to 50 (or 0,15€). 

On November 12, 1997 LOTTO gets revamped. A new prize category (triples) as well as a new lowest prize of 100 drachmas (0,30€) for the winners of all prize categories, are introduced.

From January 26, 2009 the new redesigned play slip offers more options to the players and the ability to participate in consecutive and future draws.
Moreover a new prize category (5+1), with fixed prizes per winning ticket (for the 5+1, 5,4,3 prize categories) is established. 
The column price is fixed at 0,50€.

In April 2023, opaponline.gr is launched, offering players the chance to submit their slip online, through opaponline.gr and mobile app

In October 2023, after 33 years, Lotto changes to acquire its own character. It converts from a jackpot game to a monthly installment game and offers 10.000€ per month for 10 years in the first category in each draw. In addition, the column price changes from 0,50€ to 1,00€.